To Your Health
November, 2024 (Vol. 18, Issue 11) |
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GLP-1s and Muscle Loss
By Editorial Staff
GLP-1 agonists are a class of medications that have grown incredibly popular for weight loss in the past few years. They mimic a hormone called glucagon-like peptide that assists in regulating not only appetite, but also blood sugar and digestion. According to the Cleveland Clinic, the most common side effects of GLP-1 drugs include loss of appetite, nausea, vomiting, and diarrhea.
Loss of skeletal muscle mass may be another side effect of GLP-1 use, according to conclusions published in the research journal The Lancet. The authors suggest that among total weight loss, as much as 25-39% may be due to muscle loss (fat-free mass). They also suggest that this muscle loss is much higher than what is typically seen with non-drug caloric restriction or normal aging.
The takeaway: GLP-1 use for weight loss should be a carefully considered conversation with your health care provider and only considered in extreme cases (morbid obesity, uncontrolled diabetes, etc.). Non-drug interventions such as dietary changes and exercise remain the gold standards for addressing excess weight. If you've been struggling with your weight and are considering GLP-1 use, talk to your doctor about non-drug options and ask for assistance outlining a diet and exercise plan effective for your needs.
